A personalised approach to recognizing advanced Parkinson’s

Parkinson’s disease (PD) is a neurodegenerative disease characterised by different stages, which are frequently established by the age of onset.

First CSF collection

Last week, the clinical team of the Luxembourg Parkinson’s Study reached a new milestone. For the first time in Luxembourg, cerebral spinal fluid (CSF), the fluid that surrounds the brain and spinal cord, has been collected for research purposes.

Parkinson’s disease is an insidious disease: by the time it manifests as the typical motor dysfunctions such as tremors or muscle rigidity, portions of the brain have already been irreversibly destroyed. By this stage, the disease will have often begun already decades earlier.

Patient engagement in the clinical research of the Luxembourg Parkinson’s Study (NCER-PD) is of vital importance for its success.

It has been known for a while that in Parkinson’s diseases disturbances arise in the mitochondria (‘energy plants’) and lysosomes (‘garbage trucks’) of the dopamine-producing cells. But how are these two disturbances connected and why do they cause the same disease?